Introduction

If you’ve been diagnosed with heart failure, especially with reduced ejection fraction (meaning your heart's ejection fraction is less than 40%), it's essential to understand the medications your doctor may prescribe. These medications are designed to help you live longer, feel better, and manage your condition effectively. Let’s break down these medications into four key groups, plus one bonus medication that may also be recommended.

The 4 Key Pillars of Heart Failure Medications

1. Beta Blockers

These medications help your heart pump more efficiently by improving its structure and function (known as "cardiac remodeling"). The three common beta blockers are:

• Carvedilol (Coreg)

• Bisoprolol

• Metoprolol Succinate (Toprol XL)

Why they matter:

Beta blockers have been shown to reduce the risk of death in patients with heart failure, helping you live longer.

2. Renin-Angiotensin System Inhibitors

These medications include ACE inhibitors, ARBs, and ARNIs.

• ACE inhibitors: Examples include Lisinopril and Enalapril.

• ARBs: Examples include Losartan.

• ARNI: The only approved medication in this category is Entresto.

Why they matter:

These medications reduce fluid buildup, prevent heart failure exacerbations, and decrease the chances of hospitalization. They also contribute to improved survival rates.

3. SGLT2 Inhibitors

Initially used for diabetes, SGLT2 inhibitors have been found to protect the heart as well. Common examples include:

• Jardiance

• Farxiga

Why they matter:

These medications help lower the risk of heart failure hospitalizations and reduce fluid buildup, even in patients without diabetes.

4. Mineralocorticoid Receptor Antagonists (MRAs)

This group includes:

• Spironolactone

• Eplerenone

Why they matter:

MRAs reduce the risk of cardiovascular complications, helping to stabilize your condition.

The Bonus Medication: Diuretics

While not one of the core pillars, diuretics are often used to manage fluid buildup. Common examples are:

• Lasix (Furosemide)

• Torsemide

Why they matter:

Diuretics help your body get rid of excess fluid by increasing urination. This can help reduce swelling and breathing difficulties.

Why It’s Important to Stick with Your Medications

Heart failure medications are lifelong commitments. Studies show that patients who consistently take all four core medications experience better outcomes and live longer. These medications can improve your energy levels, breathing, and overall quality of life, helping you stay out of the hospital.

If you experience side effects, talk to your doctor—there may be alternatives that suit you better.

Taking Control of Your Heart Health

If you’ve recently been diagnosed with heart failure, it's crucial to stay informed and proactive in managing your treatment. Work with your healthcare team, ask questions, and ensure you’re on the best regimen for your health.

For more resources on managing heart failure, download our free heart health guide.

Remember: Consistent medication use and close communication with your healthcare provider can make a significant difference in your journey to better heart health.